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Published on: August 28, 2018
Thrombelastogram are associated with coronary artery aneurysm in Kawasaki disease patients
Yue Peng1, Jinhui Wu1, Xue Zhou2
1Department of Cardiovascular Medicine of Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Key Laboratory of Children's Important Organ Development and Diseases of Chongqing Municipal Health Commission, National Clinical Key Cardiovascular Specialty, Chongqing, 400014, China.
Insights
Thromboelastography maximum amplitude (MA) may predict coronary artery aneurysms (CAA) in children with Kawasaki disease (KD). This finding could improve early detection and management of KD complications.
Area of Science:
- Pediatric Cardiology
- Hemostasis and Thrombosis
- Rheumatology
Background:
- Kawasaki disease (KD) is a pediatric illness affecting coronary arteries, potentially leading to coronary artery aneurysms (CAA).
- Early identification of KD patients at risk for CAA is crucial for timely intervention.
Purpose of the Study:
- To investigate the association between thromboelastography maximum amplitude (MA) and the development of CAA in KD patients.
- To determine if thromboelastography MA can serve as a predictive marker for CAA in KD.
Main Methods:
- A cohort of 243 KD patients was analyzed retrospectively.
- Multivariable logistic regression identified independent risk factors for CAA.
Main Results:
- Thromboelastography MA, age, albumin levels, and IVIG resistance were significantly different in patients with CAA compared to those without.
- MA was independently associated with CAA in KD patients (Adjusted OR 1.846; P = 0.028).
Conclusions:
- Thromboelastography MA shows a significant relationship with CAA in Kawasaki disease.
- Thromboelastography MA may serve as a valuable predictor for CAA development in KD patients.
Background:
Kawasaki disease (KD) is a common pediatric disease that readily affects the coronary arteries and can progress to form coronary artery aneurysms (CAA). This study aimed to explore the relationship between thromboelastography MA and CAA and to ascertain whether thromboelastography MA could act as a predictor of CAA in KD patients.
Methods:
A total of 243 consecutive KD patients from January 2020 to December 2022 were included in this study. Differences in baseline characteristics were compared through analysis, and subsequent multivariable logistic regression analysis was performed to identify independent risk factors for CAA in KD patients.
Results:
Among the 243 KD patients, 107 were female and 136 were male, with a median age of 23 months. Differential analysis indicated that the R, K, α, gender, WBC, HB, PLT and NLR were not significantly different, but the MA, age, IVIG resistance, CRP and albumin were significantly different between the KD-CAA and the KD-NCAA groups. Subsequent multivariable logistic regression analysis showed that age (Adjusted OR 0.988; 95% CI, 0.977-0.999; P = 0.039), albumin (Adjusted OR 0.902; 95% CI, 0.852-0.956; P < 0.001) and MA (Adjusted OR 1.846; 95% CI, 1.069-3.187; P = 0.028) were independently associated with CAA in KD patients.
Conclusion:
Thromboelastography MA is closely related to CAA and may be a predictor of CAA in KD patients.
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