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Exploring Mechanistic Insights by Carotenoids in Neuropathic and Inflammatory Pain

Fatemeh Abbaszadeh1, Masoumeh Jorjani1,2, Roshanak Amirian3,4

  • 1Neurobiology Research Center, Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Current Neuropharmacology
|July 4, 2025
PubMed

Insights

Carotenoids, natural compounds found in foods, show promise in managing chronic pain by reducing inflammation and oxidative stress. This review explores their potential as multi-target nutraceuticals for pain relief.

Area of Science:

  • Nutritional Science
  • Pharmacology
  • Pain Management

Background:

  • Chronic pain significantly impacts quality of life, with current treatments often having side effects.
  • Existing pain conditions involve multiple dysregulated pathways, necessitating novel multi-target therapeutic agents.
  • Carotenoids, natural pigments from foods, possess antioxidant and anti-inflammatory properties.

Purpose of the Study:

  • To review the potential of carotenoids and their derivatives as natural nutraceuticals for managing inflammation and relieving pain.
  • To explore the mechanisms of action through which carotenoids exert beneficial effects in preclinical and clinical studies.

Main Methods:

  • Comprehensive literature review of preclinical and clinical studies on carotenoids and pain.
  • Analysis of carotenoid mechanisms targeting inflammation, oxidative stress, and pain signaling pathways.

Main Results:

  • Carotenoids demonstrate efficacy in alleviating pain hypersensitivity.
  • They effectively reduce inflammation and oxidative stress, key factors in chronic pain.
  • Carotenoids modulate crucial pain-related signaling pathways.

Conclusions:

  • Carotenoids show significant potential as natural nutraceuticals for chronic pain management.
  • Further clinical trials investigating carotenoids for pain relief are warranted.
  • This review supports the application of carotenoids in future pain management strategies.
Keywords:
Carotenoidsclinical profiledrug of futureinflammatory painneuropathic painsignaling pathway

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