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The Interaction between miRNAs and 14-3-3ζ Protein in Different Diseases
Ahmad Fazilat1, Alireza Soleimani Mamalo2, Salomeh Roshani3
1Department of Genetics, Motamed Cancer Institute, Breast Cancer Research Center, ACECR, Tehran, Iran.
Abstract:
Members of the 14-3-3 protein family are involved in various cellular processes, including migration, angiogenesis, cell cycle, apoptosis, and signal transduction. Nevertheless, the 14-3-3 family possibly plays a fundamental role in the development of diseases and cancer by regulating various biological pathways. MicroRNAs (miRNAs) are mainly transcribed by RNA polymerase II (pol II), with only a few exceptions involving RNA polymerase III (pol III). They can control cell mechanisms through different pathways. miRNAs inhibit or destroy mRNAs by binding to them. They control intracellular mechanisms by binding to molecules such as the 14-3-3ζ protein. miRNAs play a role in regulating this protein, and by inducing or suppressing it, they contribute to either the development or the prevention of the diseases. Therefore, considering the importance of the 14-3-3ζ protein in different pathways within the body, we decided to investigate the relationship between miRNAs and 14-3-3ζ and clarify their interactions, in this review.
Insights
MicroRNAs (miRNAs) regulate the 14-3-3ζ protein, influencing disease and cancer development. Understanding these interactions is crucial for disease prevention and treatment strategies.
Area of Science:
- Molecular Biology
- Cellular Biology
- Biochemistry
Background:
- The 14-3-3 protein family regulates critical cellular processes like migration, angiogenesis, cell cycle, apoptosis, and signal transduction.
- Dysregulation of the 14-3-3 protein family is implicated in disease and cancer development through various biological pathways.
- MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by targeting messenger RNAs (mRNAs).
Purpose of the Study:
- To investigate the intricate relationship between microRNAs (miRNAs) and the 14-3-3ζ protein.
- To clarify the regulatory interactions between miRNAs and 14-3-3ζ.
- To understand the role of these interactions in disease pathogenesis and potential prevention.
Main Methods:
- Literature review focusing on molecular mechanisms of miRNA-mediated gene regulation.
- Analysis of studies examining miRNA binding sites on 14-3-3ζ mRNA.
- Review of experimental data demonstrating the impact of miRNA modulation on 14-3-3ζ expression and cellular functions.
Main Results:
- miRNAs directly bind to 14-3-3ζ mRNA, leading to its inhibition or degradation.
- Specific miRNAs have been identified as either inducers or suppressors of 14-3-3ζ expression.
- Modulation of 14-3-3ζ by miRNAs affects cellular processes relevant to disease, including proliferation and apoptosis.
Conclusions:
- miRNAs are key regulators of 14-3-3ζ, impacting cellular homeostasis.
- The interplay between miRNAs and 14-3-3ζ represents a significant factor in the development or prevention of various diseases, including cancer.
- Targeting miRNA-14-3-3ζ interactions may offer novel therapeutic strategies for disease management.
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