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Evaluation of Cardiac Autonomic Function in Patients With Alteration in Thyroid Hormones: Systematic Literature

Marianne Lucena da Silva1, Nádia Martins de Paula Souza2, Miguel Luciano Rodrigues da Silva Júnior3

  • 1Collective Health Department, University of Brasilia, Brasilia, Brazil.

Clinical Endocrinology
|July 4, 2025
PubMed

Insights

Thyroid hormonal disorders like hypothyroidism and hyperthyroidism reduce heart rate variability, indicating decreased cardiac adaptive capacity. This impacts autonomic nervous system modulation of the cardiovascular system.

Area of Science:

  • Endocrinology
  • Cardiology
  • Autonomic Neuroscience

Background:

  • Thyroid hormonal disorders are prevalent and significantly impact cardiovascular function.
  • These dysfunctions alter autonomic nervous system activity, affecting heart rate variability (HRV).

Purpose of the Study:

  • To systematically investigate the influence of thyroid hormonal dysfunctions on cardiac autonomic activity modulation.
  • To analyze how conditions like hypothyroidism and hyperthyroidism affect heart rate variability.

Main Methods:

  • A comprehensive systematic review of studies was conducted across major electronic databases.
  • Included are non-randomized clinical trials analyzing heart rate variability in human subjects with thyroid disease.

Main Results:

  • Fifteen studies were included from over ten thousand initially identified items.
  • Hypothyroidism and hyperthyroidism were associated with reduced heart rate variability.
  • This reduction suggests diminished adaptive capacity of the heart.

Conclusions:

  • Both hypothyroidism and hyperthyroidism impair cardiac autonomic modulation, leading to decreased HRV.
  • Variability in available time and frequency domain data was noted across studies.
Abstract

Keywords:
heart ratehyperthyroidismhypothyroidismsystematic review

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