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Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
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NT-proBNP and BNP Testing in Pulmonary Arterial Hypertension: Point-of-Care and Remote Monitoring
Charlotte Durrington1,2, Christian Battersby1, Laura Holt1
1Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Respirology (Carlton, Vic.)
|July 4, 2025
Summary
Point-of-care N-terminal prohormone of brain natriuretic peptide (NT-proBNP) tests are reliable for pulmonary arterial hypertension (PAH) patients. NT-proBNP is also stable in mailed samples, supporting remote monitoring for PAH.
Area of Science:
- Cardiology
- Pulmonary Medicine
- Biomarker Analysis
Background:
- Brain natriuretic peptide (BNP) and N-terminal prohormone of BNP (NT-proBNP) are key biomarkers for pulmonary arterial hypertension (PAH).
- Timely biomarker results are crucial for clinical assessment but often delayed.
- Investigating the reliability of point-of-care tests (POCT) and mailed samples for NT-proBNP is essential for efficient PAH management.
Purpose of the Study:
- To assess the reliability of NT-proBNP and BNP point-of-care tests (POCT) in PAH patients.
- To determine the stability of NT-proBNP in blood samples sent via mail for remote monitoring.
- To compare the diagnostic accuracy of NT-proBNP and BNP in risk stratification for PAH.
Main Methods:
- Prospective recruitment of Group 1 PAH patients.
- Comparison of laboratory and POCT NT-proBNP/BNP measurements.
- Analysis of NT-proBNP stability in postal samples and impact of exercise.
- Intraclass correlation coefficient (ICC) and Passing-Bablok regression for agreement assessment.
Main Results:
- NT-proBNP POCT and laboratory results showed excellent agreement (ICC=0.97).
- BNP POCT and laboratory results demonstrated non-equivalence.
- NT-proBNP showed good agreement in postal samples, unaffected by exercise.
- NT-proBNP risk stratification was more sensitive than BNP.
Conclusions:
- POCT NT-proBNP is a dependable and accessible alternative for clinical PAH assessment.
- NT-proBNP analysis from mailed samples shows promise for remote patient monitoring.
- NT-proBNP is a more effective biomarker for PAH risk stratification than BNP.
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