Related Experiment Video
Updated: Sep 17, 2025

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
Published on: June 9, 2018
A robust and efficient change point detection method for high-dimensional linear models
Zhong-Cheng Han1, Kong-Sheng Zhang2, Yan-Yong Zhao1
1School of Statistics and Mathematics, Nanjing Audit University, Nanjing, People's Republic of China.
This study introduces modal linear regression for high-dimensional data, efficiently estimating differing regression coefficients across subpopulations. The method also performs variable selection and change point detection for robust analysis.
Area of Science:
- Statistics
- Econometrics
- Machine Learning
Background:
- Estimating regression coefficients is crucial in linear models.
- Unknown coefficient parameters can vary across different segments of data.
- High-dimensional covariates pose challenges in traditional regression analysis.
Purpose of the Study:
- To propose a novel method for analyzing linear models with potentially different regression coefficients in two subpopulations, especially in high-dimensional settings.
- To introduce modal linear regression for robust and efficient estimation of unknown coefficient parameters.
- To develop a method capable of variable selection and change point detection.
Main Methods:
- Modal linear regression is introduced for parameter estimation.
- Variable selection and change point detection are integrated into the proposed method.
- An estimation algorithm combining kick-one-off and SCAD approaches is developed.
Main Results:
- The proposed modal linear regression method offers robustness and efficiency.
- The method demonstrates capability in variable selection and change point detection.
- The limiting behavior of the proposed method is established under mild assumptions.
Conclusions:
- Modal linear regression provides an effective approach for high-dimensional linear models with varying coefficients.
- The developed algorithm facilitates practical implementation and assessment via simulations and real data analysis.
- The study contributes a versatile tool for analyzing segmented data with complex coefficient structures.
More Related Videos
Related Concept Videos
Difference from Background: Limit of Detection
The LOD indicates the presence or absence...
Calibration Curves: Linear Least Squares
For data that follow a straight line, the standard method for fitting is the linear...
Outliers and Influential Points
Regression Toward the Mean
Point and Frameshift Mutations
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...

