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Updated: Sep 17, 2025

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
Published on: June 9, 2018
A robust and efficient change point detection method for high-dimensional linear models
Zhong-Cheng Han1, Kong-Sheng Zhang2, Yan-Yong Zhao1
1School of Statistics and Mathematics, Nanjing Audit University, Nanjing, People's Republic of China.
Abstract:
In the context of linear models, a key problem of interest is to estimate the regression coefficient. Nevertheless, in certain instances, the vector of unknown coefficient parameters in a linear regression model differs from one segment to another. In this paper, when the dimension of covariates is high, a new method is proposed to examine a linear model in which the regression coefficient of two subpopulations may be different. To achieve robustness and efficiency, we introduce modal linear regression as a means of estimating the unknown coefficient parameters. Furthermore, our proposed method is capable of selecting variables and checking change points. Under certain mild assumptions, the limiting behavior of our proposed method can be established. Additionally, an estimation algorithm based on kick-one-off and SCAD approach is developed to implement in practice. For illustration, simulation studies and a real data are considered to assess the performance of our proposed method.
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