Related Experiment Video
Updated: Sep 17, 2025
Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
Published on: October 28, 2022
The Value of Netrin-1 and Neuron Specific Enolase biomarkers in neonates with Hypoxic İschemic Encephalopathy
Ahmed Sobhi1, Ashraf Hamed Al-Shokary2, Moustafa Kotb Elmala3
1Cairo University, Egypt.
Objective:
To investigate netrin-1 (NT-1) and neuron-specific enolase (NSE) in the umbilical cord as biomarkers in HIE stage II/III.
Materials And Methods:
We included 100 infants with HIE stage II/III and 100 controls. Cord samples were taken to determine the levels of NT-1 and NSE.
Results:
The HIE group showed significantly higher NT-1 (343.3 ± 100.6 pg/mL) and NSE (55.17 ± 13.4 ng/mL; P = .037, P = .007, respectively) than the control group, which had NT-1 (268.1 ± 79.3 pg/mL) and NSE (31.3 ± 19.5 ng/mL). The cut-off values for NT-1 and NSE were 289.3 pg/mL and 31.9 ng/mL, respectively. NT-1 had a sensitivity of 92%, a specificity of 100%, a positive predictive value (PPV) of 94%, and a negative predictive value (NPV) of 100%. The sensitivity, specificity, PPV, and NPV for NSE were all 100%.
Conclusion:
NT-1 and NSE can be reliable biomarkers for predicting HIE stage II/III.
