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Updated: Sep 17, 2025

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
Association between glycemia risk index and carotid intima-media thickness in type 2 diabetes
Lingyun Zhao1,2, Hongyan Heng2, Qinyuan Xie1,2
1Department of Endocrinology, Zhengzhou University People's Hospital, Zhengzhou, China.
Objective:
To investigate the association between the Glycemic Risk Index (GRI) and carotid intima-media thickness (CIMT) in type 2 diabetes mellitus (T2DM) patients and evaluate the clinical utility of GRI for early vascular risk assessment.
Methods:
This retrospective study included 450 previously untreated patients with T2DM prior to hospitalization. We calculated GRI using CGM data and assessed CIMT with high-resolution ultrasound. Multiple linear and logistic regression analyses assessed the association between GRI and CIMT. Receiver operating characteristic (ROC) curve analyses evaluated GRI's predictive performance.
Results:
There was a significant positive correlation between GRI and CIMT (r = 0.42, P < 0.001). After adjusting for confounders, GRI remained an independent predictor of CIMT thickening (OR = 7.226, 95% CI: 5.597-8.856, P < 0.001). ROC analysis revealed that GRI alone predicted abnormal CIMT with an AUC of 0.869.
Conclusion:
GRI is a robust marker for predicting CIMT thickening in T2DM patients, providing a novel approach for cardiovascular risk stratification. This study underscores the potential of integrating GRI into routine diabetes management to improve vascular outcomes.
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