Apelin facilitates integrin αvβ3 production and enhances metastasis in prostate cancer by activating STAT3 and inhibiting miR-8070
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View abstract on PubMed
Summary
This summary is machine-generated.Apelin elevates integrin αvβ3 in prostate cancer, driving metastasis. Inhibiting apelin reduces tumor spread, suggesting the apelin/integrin pathway as a therapeutic target for advanced prostate cancer.
Area Of Science
- Oncology
- Molecular Biology
- Cell Biology
Background
- Prostate cancer is a leading cancer in men, frequently metastasizing in advanced stages.
- Integrins are cell surface receptors crucial for cell adhesion and migration.
- Apelin, an adipokine, is linked to cancer progression, but its role in prostate cancer metastasis via integrin regulation is unclear.
Purpose Of The Study
- To investigate the role of apelin in regulating integrin expression and prostate cancer cell migration.
- To elucidate the molecular mechanisms underlying apelin-mediated prostate cancer metastasis.
- To evaluate the therapeutic potential of targeting the apelin/integrin axis in metastatic prostate cancer.
Main Methods
- Quantitative analysis of apelin and integrin αvβ3 expression in prostate cancer tissues.
- In vitro studies assessing the effect of apelin stimulation on prostate cancer cell migration.
- Investigation of signaling pathways including MAPK, STAT3, and miR-8070.
- In vivo studies using animal models to assess the impact of apelin inhibition on metastasis.
Main Results
- Apelin and integrin αvβ3 expression are upregulated in prostate cancer tissues.
- Apelin enhances integrin αvβ3-dependent prostate cancer cell migration.
- Apelin-induced integrin synthesis and cell motility are mediated by MAPK pathway activation and miR-8070 inhibition.
- Inhibition of apelin reduces integrin αvβ3 expression and prostate cancer metastasis in vivo.
Conclusions
- The apelin/integrin αvβ3 axis plays a significant role in promoting prostate cancer cell migration and metastasis.
- Targeting the apelin signaling pathway offers a potential therapeutic strategy for inhibiting prostate cancer metastasis.
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