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Updated: Sep 17, 2025
07:51
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
217
Cannabis tolerance reduces symptom relief.
Sarah S Stith1, Xiaoxue Li1, Franco Brockelman2
1Department of Economics, University of New Mexico, Albuquerque, NM, United States.
Frontiers in Pharmacology
|July 4, 2025
Summary
Repeated medical cannabis use decreases symptom relief over time, though side effects may improve. Adjusting THC levels and dosage can personalize treatment for better outcomes.
Area of Science:
- Medical cannabis research
- Pharmacology
- Symptom management
Background:
- Tolerance to medical cannabis can impact treatment efficacy.
- Understanding how repeated use affects symptom relief is crucial for patient care.
Purpose of the Study:
- To quantify the impact of repeated medical cannabis consumption on acute symptom management.
- To investigate the relationship between session count and symptom relief.
Main Methods:
- Utilized the Releaf App to collect data from 16,395 medical cannabis patients.
- Analyzed 120,691 treatment sessions using fixed effects least-squares regression.
- Recorded symptoms, product details, consumption methods, cannabinoid levels, dosing, and side effects.
Main Results:
- A 0.5% average decrease in symptom relief per session was observed.
- Combustible products, higher doses, and higher THC levels correlated with greater relief.
- Experienced users primarily drove the observed effects on symptom relief.
Conclusions:
- Most patients experience reduced symptom relief with repeated medical cannabis use.
- Improvements in negative side effects may counterbalance decreased symptom relief.
- Optimizing THC levels and dosage can enhance medical cannabis treatment outcomes.
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