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Updated: Sep 17, 2025

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy
Published on: May 22, 2020
Role of meningeal lymphatic vessels in brain homeostasis
Meng-Ying Zhao1, Chao-Yuan Ye1, Yuan-Cheng Liu1
1Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Abstract:
Meningeal lymphatic vessels (MLVs) form an important bridging structure between the brain and periphery, which drains cerebral metabolites in cerebrospinal fluid (CSF) and brain antigens to deep cervical lymph nodes (dCLNs), to maintain brain homeostasis. Increasing evidence reveals the importance of MLVs in brain ageing and various central nervous system (CNS) diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), traumatic brain injury (TBI), and multiple sclerosis (MS). Advances in research techniques have provided detailed insights into the structure and functions of MLVs, highlighting the therapeutic potential of targeting MLVs for related diseases. Here, we perform a systematic review of the features and functional regulation of MLVs, their associations with brain disorders, as well as some methodological advances in imaging of MLVs and the drainage pathway.
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