[Correlation between Serum FGF-23, HPSE Levels and Early Renal Impairment in Patients with Multiple Myeloma]
Li-Fang Ma1, Yan Yun1, Yan-Qi Liu1
1Department of Hematology, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010, Inner Mongolia Autonomous Region, China.
Objective:
To investigate the relationship between serum levels of fibroblast growth factor-23 (FGF-23), heparanase (HPSE) and early renal impairment (RI) in patients with multiple myeloma (MM).
Methods:
A retrospective analysis was conducted on the clinical data of 125 MM patients who were initially diagnosed in the Department of Hematology of the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology from June 2020 to June 2023. The patients were divided into RI group (>176.80 μmol/L) and non-RI group (≤176.80 μmol/L) based on their serum creatinine levels when diagnosed. The baseline data and laboratory indexes of the two groups were compared. The relationship between serum FGF-23, HPSE and early RI in MM patients was analyzed.
Results:
Among 125 newly diagnosed MM patients, 33 cases developed early RI, accounting for 26.40%. The proportion of light chain type, blood urea nitrogen (BUN), blood uric acid, lactate dehydrogenase, FGF-23, and HPSE levels in RI group were higher than those in non-RI group (all P <0.05). There was no statistical significant difference in other data between the two groups (P >0.05). Multivariate logistic regression analysis showed that BUN, FGF-23 and HPSE were associated with early RI in MM patients (all P <0.05). The serum FGF-23 level was divided into Q1-Q4 groups by quartile, and the serum HPSE level was divided into q1-q4 groups. The correlation analysis showed that with the increase of serum FGF-23 and HPSE levels, the incidence of early RI increased (r =0.668, 0.592). Furthermore, logistic regression analysis showed that after controlling for confounding factors, elevated levels of serum FGF-23 and HPSE were still influencing factors for early RI in MM patients (OR>1, P <0.05). According to Pearson's linear correlation test, there was a positive correlation between serum FGF-23 level and HPSE level (r =0.373).
Conclusion:
There is a certain correlation between serum levels of FGF-23, HPSE and early RI in MM patients, and the incidence of early RI is higher in patients with abnormally high levels of both.
Insights
Serum levels of fibroblast growth factor-23 (FGF-23) and heparanase (HPSE) are linked to early renal impairment (RI) in multiple myeloma (MM) patients. Higher levels of both FGF-23 and HPSE correlate with an increased incidence of RI in MM.
Area of Science:
- Hematology
- Nephrology
- Biochemistry
Context:
- Multiple myeloma (MM) is a hematological malignancy.
- Early renal impairment (RI) is a common complication in MM patients.
- Understanding biomarkers for early RI is crucial for patient management.
Purpose:
- To investigate the relationship between serum levels of fibroblast growth factor-23 (FGF-23) and heparanase (HPSE) and early renal impairment (RI) in patients with multiple myeloma (MM).
Summary:
- A retrospective analysis of 125 MM patients revealed that 26.40% developed early RI.
- Elevated serum levels of FGF-23 and HPSE were significantly associated with early RI in MM patients.
- Multivariate analysis confirmed FGF-23 and HPSE as independent risk factors for early RI, with a positive correlation between their levels and RI incidence.
Impact:
- Identifies FGF-23 and HPSE as potential biomarkers for early detection of renal impairment in MM.
- Provides insights into the pathophysiology of RI in MM.
- May inform future therapeutic strategies aimed at preventing or mitigating renal damage in MM patients.
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