Photoinduced Plasmon Electron Transfer-based Bioorthogonal Cleavage Reaction for Precision Tumor Therapy

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Photocatalysis

Background:

• Photocatalytic cancer therapy shows promise but requires enhanced catalytic activity in biological settings.
• Developing precise and controllable therapeutic strategies is crucial for effective cancer treatment.

Purpose of the Study:

• To develop a spatiotemporally controllable photocatalytic cancer therapy using a novel photoinduced plasmon electron transfer (PiPET) mechanism.
• To enhance the catalytic activity of methylene blue (MB) for improved cancer treatment efficacy.

Main Methods:

• Utilized palladium-conjugated gold nanobipyramids to facilitate electron transfer and improve catalytic activity.
• Investigated the photoinduced plasmon electron transfer (PiPET) in a biorthogonal cleavage reaction of allyl carbamate-conjugated methylene blue (MB).
• Simulated electron transfer processes to optimize catalytic performance.

Main Results:

• Achieved a ninefold enhancement in the release of allyl carbamate-conjugated methylene blue.
• Demonstrated precise spatiotemporal control of the bioorthogonal reaction in vivo.
• Exhibited remarkable tumor-suppressing capabilities in both in vitro and in vivo studies through combined photothermal and PiPET effects.

Conclusions:

• The PiPET-based biorthogonal cleavage reaction offers an innovative approach for precise tumor therapy.
• Spatiotemporal control in phototherapeutics can significantly enhance treatment efficacy.
• This strategy effectively suppresses tumors by leveraging photothermal effects and preventing leuko-MB formation.