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Updated: Sep 17, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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Epigenetic Mechanisms in Neuroendocrine Neoplasms: Is There a Place for Inhibitors of DNA Binding Proteins?

David Sanchis-Pascual1, María Isabel Del Olmo-García1,2, Pilar Morillas-Amat3

  • 1Endocrinology and Nutrition Department, University and Politecnic Hospital La Fe (Valencia), 46026 Valencia, Spain.

Frontiers in Bioscience (Landmark Edition)
|July 4, 2025
PubMed

Insights

Inhibitors of DNA-binding (Id) proteins are overexpressed in neuroendocrine neoplasms (NENs), suggesting their potential as diagnostic biomarkers and therapeutic targets for these aggressive tumors.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Pathogenesis

Background:

  • Inhibitors of DNA-binding (Id) proteins are repressor factors influencing cellular processes.
  • Id proteins are implicated in tumor aggressiveness, chemotherapy resistance, and poor prognosis across malignancies.

Purpose of the Study:

  • To review the role of Id proteins in the pathogenesis of neuroendocrine neoplasms (NENs).
  • To highlight Id proteins as potential diagnostic and therapeutic targets for NENs.

Main Methods:

  • Literature review focusing on Id protein expression and regulation in NENs.
  • Analysis of existing data on Id protein involvement in small cell lung carcinoma, neuroendocrine prostate carcinoma, and medullary thyroid carcinoma.

Main Results:

  • Significant overexpression of Id proteins was observed in small cell lung carcinoma (SCLC), neuroendocrine prostate carcinoma (NEPC), and medullary thyroid carcinoma (MTC).
  • The epigenetic regulation of Id proteins in NENs is largely uncharacterized, with limited data primarily from NEPC.

Conclusions:

  • Id proteins represent promising diagnostic biomarkers and therapeutic targets for NEN management.
  • Further research is crucial to elucidate the epigenetic regulation and comprehensive role of Id proteins in NENs.
Keywords:
IdId proteincancerepigeneticsneuroendocrine neoplasm

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