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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

344
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Related Experiment Video

Updated: Sep 17, 2025

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

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Mean Corpuscular Volume and Risk of Autism Spectrum Disorder.

Ülgen S Fideli1, Ann I Scher1, William W Young2

  • 1Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition
|July 4, 2025
PubMed
Summary
This summary is machine-generated.

Elevated mean corpuscular volume (MCV) in children, but not mothers, is linked to higher autism spectrum disorder (ASD) risk. This finding suggests MCV could be an early biomarker for identifying at-risk infants.

Keywords:
autism spectrum disorderfolatemean corpuscular volumeneurodevelopmental disordersnutritionvitamin B12

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Area of Science:

  • Neurodevelopmental disorders
  • Pediatric medicine
  • Hematology

Background:

  • Autism spectrum disorder (ASD) diagnosis is typically made after age two.
  • Currently, no laboratory tests exist to identify mothers at high risk for ASD or infants before symptom onset.
  • Vitamin B12 and folate deficiency, leading to macrocytic anemias, are known risk factors for neurodevelopmental disorders.

Purpose of the Study:

  • To investigate the association between increased mean corpuscular volume (MCV) and the likelihood of an ASD diagnosis.
  • To determine if maternal or child MCV levels correlate with increased odds of ASD.

Main Methods:

  • Evaluated MCV values in mothers (one year pre-birth) and children (birth to follow-up).
  • Calculated maternal mean MCV (mMCV) and child mMCV.
  • Used logistic regression models to estimate odds ratios and 95% confidence intervals.

Main Results:

  • Maternal MCV one year before birth showed no association with subsequent ASD diagnosis in children.
  • In children, elevated mMCV levels (81 fL, 84 fL, 91 fL) were associated with increased odds of ASD (26%, 38%, 32% respectively) compared to a reference of 76 fL.
  • The study included 3798 mothers and 9633 children.

Conclusions:

  • Increased child MCV may serve as a potential, inexpensive biomarker for identifying children at risk of ASD.
  • This exploratory research supports further investigation into the clinical utility of MCV for early detection of developmental disorders.