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Effect of diet on gastric secretion
The American Journal of Clinical Nutrition
|November 1, 1985
Summary
Meals significantly stimulate gastric acid secretion, with protein meals being potent stimulants. Factors like meal characteristics and fat content influence this response, mediated by vagus nerves and gastrin.
Area of Science:
- Gastroenterology
- Physiology
Background:
- Meals are known stimulants of gastric acid secretion in humans and animals.
- Gastric pH is lowest in the early morning hours.
- Protein meals buffer gastric pH initially but stimulate acid secretion as they empty.
Purpose of the Study:
- To explore the mechanisms and characteristics of meal-stimulated gastric acid secretion.
- To compare meal-stimulated acid secretion with maximal responses to pharmacological agents.
Main Methods:
- Intragastric titration and marker dilution methods were used to measure human gastric acid output.
- Studies involved various meal compositions and characteristics.
Main Results:
- Acid secretion in response to meals can equal or exceed maximal responses to histamine and pentagastrin in different species.
- Fat in meals delays the acid secretory response.
- Appetizing qualities and meal characteristics influence acid secretion.
Conclusions:
- Meal composition, particularly protein and fat content, significantly impacts gastric acid secretion.
- Neural (vagus nerves) and hormonal (gastrin) pathways mediate meal-stimulated acid secretion.