Enantioselective Palladium-Catalyzed Domino Carboetherification Reaction: Access to Isoxazoline-Linked
Lei Wang1, Yanru He1, Huirong Li1
1School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China.
None:
Herein, we present an enantioselective domino carboetherification of β,γ-unsaturated oxime derivatives under mild reaction conditions. This process, catalyzed by palladium in combination with Sadphos ligands, offers a concise and highly efficient route for the assembly of chiral isoxazoline-linked methylenedihydrobenzofuran and methyleneindolin bis-heterocyclic scaffolds. The methodology demonstrates excellent functional group tolerance, a broad substrate scope, and high chemoselectivity and enantioselectivity.
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