Trichosporon and Antifungal Resistance: Current Knowledge and Gaps

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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

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Isabela Lima Miranda1, Nalu Teixeira Aguiar Peres1,2, Rafael Wesley Bastos2,3

  • 1Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.

Mycopathologia
|July 4, 2025
PubMed

Insights

Trichosporon fungi cause infections like White Piedra and fungemia. High antifungal resistance necessitates new treatments and understanding of resistance mechanisms in Trichosporon spp.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Trichosporon spp. are opportunistic fungi found in human microbiota.
  • They cause superficial (White Piedra) and deep-seated infections (fungemia).
  • Existing antifungals show limited efficacy against Trichosporon.

Purpose of the Study:

  • To review antifungal resistance in Trichosporon spp.
  • To explore the mechanisms underlying this resistance.
  • To identify areas for future research in Trichosporon pathogenesis.

Main Methods:

  • Literature review of antifungal resistance in Trichosporon.
  • Analysis of reported resistance mechanisms.
  • Discussion of clinical implications and future research directions.

Main Results:

  • Trichosporon spp. exhibit high levels of antifungal resistance.
  • Mechanisms include biofilm formation and efflux pump overexpression.
  • Voriconazole is recommended, but resistance is a growing concern.

Conclusions:

  • Significant antifungal resistance in Trichosporon spp. requires novel therapeutic strategies.
  • Further research into resistance mechanisms is crucial for effective treatment.
  • Understanding Trichosporon pathogenesis is key to combating infections.
Keywords:
Trichosporon spp.Antifungal resistanceMechanism resistanceReview

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