[A special form of situational syncope: pertussis-induced collapse]

Pertussis, caused by Bordetella pertussis, is a severe respiratory infection which can lead to syncope as a rare but significant complication. This article provides a detailed overview of the pathophysiology, classification, diagnostic, and therapeutic challenges of pertussis-induced cough syncope and also highlights the risk of delayed diagnosis through a case presentation. The increased intrathoracic pressure during coughing episodes can lead to transient cerebral hypoperfusion and loss of consciousness, especially in elderly patients or in those with comorbidities. Autonomic nervous system dysfunction caused by the pertussis toxin may also contribute to the loss of consciousness. Accurate diagnosis relies on detailed history taking and targeted investigations, while appropriate antibiotics and vaccination are pivotal for management and prevention. Orv Hetil. 2025; 166(17): 652–657.