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Updated: Sep 16, 2025

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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SIRT3 as a potential biomarker and therapeutic target for cardiovascular diseases: a meta-analysis of clinical

Nikhil Gupta1, Vikas Kumar1, Abhinav Kanwal1

  • 1Department of Pharmacology, All India Institute of Medical Sciences, Bathinda, India.

Future Cardiology
|July 4, 2025
PubMed

Insights

Sirtuin 3 (SIRT3) levels are significantly lower in cardiovascular disease (CVD) patients. This finding highlights SIRT3

Area of Science:

  • Mitochondrial biology
  • Cardiovascular research
  • Biomarker discovery

Background:

  • Cardiovascular diseases (CVDs) are a leading cause of global mortality.
  • Mitochondrial dysfunction is a key factor in CVD pathogenesis.
  • Sirtuin 3 (SIRT3), a mitochondrial deacetylase, regulates mitochondrial function and oxidative stress.

Purpose of the Study:

  • To evaluate the association between SIRT3 levels and CVDs.
  • To elucidate SIRT3's role in CVD pathogenesis.
  • To assess SIRT3's potential as a CVD biomarker.

Main Methods:

  • Systematic literature search of MEDLINE and Embase databases (up to August 2024).
  • Adherence to PRISMA guidelines for meta-analysis.
  • Inclusion of observational studies comparing SIRT3 levels in CVD patients versus healthy controls.

Main Results:

  • 8 studies with 397 participants were included.
  • SIRT3 levels were significantly lower in individuals with CVDs (SMD: 1.08, p=0.0032).
  • The most pronounced reduction in SIRT3 was observed in hypertension and dilated cardiomyopathy.

Conclusions:

  • Compelling evidence shows significantly reduced SIRT3 levels in CVD patients.
  • SIRT3 plays a critical role in cardiovascular diseases.
  • SIRT3 holds potential as a biomarker and therapeutic target for CVDs.
Abstract

Keywords:
Cardiovascular diseasesSIRT3biomarkermeta-analysismitochondria

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