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Light-Promoted, Nickel-Catalyzed Hydrogen-Evolution C(sp3)-H Acylation of Simple Alkanes with Aromatic Aldehydes
Qiujie Shan1, Lu-Lu Chai1, David James Young2
1College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, People's Republic of China.
Abstract:
The light-promoted, nickel-catalyzed hydrogen-evolution C(sp3)-H acylation of simple alkanes with aromatic aldehydes has been achieved without the need for additional photosensitizers or oxidants. This reliable and atom-economical reaction afforded a broad range of aryl alkyl ketones in good yields, with H2 as the sole byproduct. It was successfully demonstrated on a gram scale as well as for the postfunctionalization of drug molecules. Aromatic aldehydes play multiple roles, including a photosensitizer, a coupling partner, and a hydrogen atom transfer agent.
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