Related Experiment Video
Updated: Sep 16, 2025

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
Published on: May 16, 2016
Inflammation induced by lipid mediators and protein from transfusion products
Chloe Heranney1, Mailys Portier2, Fabrice Cognasse2
1INSERM, U 1059 SAINBIOSE, Université Jean Monnet, Mines Saint-Étienne, F-42023 Saint-Etienne, France.
Purpose Of The Review:
Platelet and red blood cell (RBC) transfusions, whether used as prophylactic measures or therapeutic interventions, are critical for saving lives. However, the composition of platelet and RBC concentrates used for transfusion may contribute to adverse reactions following transfusion.
Recent Finding:
Recent studies on platelet and RBC concentrates have focused on their composition, including lipid mediators and proteins such as cytokines and chemokines, and their potential role in transfusion-related adverse reactions. This review aims to synthesize both recent and earlier findings, offering an overview of the involvement of these bioactive molecules in transfusion reactions.
Summary:
Lipid mediators and proteins could serve as predictive biomarkers for adverse reactions to specific transfusions. The integration of personalized medicine/transfusion should be explored to optimize transfusion practices and improve patient outcomes.
More Related Videos
Related Concept Videos
Inflammation
Inflammatory Response I: Vascular and Cellular
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
Allergic Drug Reactions
Myocarditis I: Introduction

