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Updated: Sep 16, 2025
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Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
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From symbiote to bad neighbor: The intestinal microbiome as a driver of CHIP
Courtney M Cowan1, Eric M Pietras2
1Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Cell Stem Cell
|July 4, 2025
Abstract:
Hematopoietic stem cells (HSCs) with mutations that can cause clonal hematopoiesis of indeterminate potential (CHIP) accumulate during aging. Agarwal et al.1 demonstrate in Nature that intestinal barrier permeability increases with age and enables the microbial metabolite ADP-heptose to reach the bone marrow, thus driving the expansion of DNMT3A-mutant HSCs.
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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
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