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Aging and Aging-Related Senescence in Liver
Souradipta Ganguly1, Sadatsugu Sakane2,3, Kanani Hokutan2,3
1Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Seminars in Liver Disease
|July 4, 2025
Summary
Liver aging involves cellular damage and inflammation, increasing disease risk. Therapies targeting cellular senescence show promise for combating age-related liver conditions.
Area of Science:
- Gerontology
- Hepatology
- Cellular Biology
Background:
- Aging leads to liver structure and function decline.
- Key aging hallmarks include genomic instability, telomere attrition, and cellular senescence.
- These changes impair liver function and increase disease susceptibility.
Purpose of the Study:
- To review the mechanisms and pathogenic effects of liver aging.
- To discuss therapeutic strategies targeting hepatic senescence.
Main Methods:
- Literature review of aging hallmarks in the liver.
- Analysis of senescence-associated secretory phenotype in liver cells.
- Examination of the role of senescent cells in liver microenvironment.
Main Results:
- Aged livers accumulate senescent cells (hepatocytes, endothelial cells, stellate cells, Kupffer cells).
- Senescence creates an inflammatory and fibrotic microenvironment, promoting tumorigenesis.
- Liver aging contributes to dysfunction, impaired regeneration, and fibrosis.
Conclusions:
- Hepatic senescence is a critical factor in liver aging and disease.
- Targeting hepatic senescence offers a promising therapeutic avenue for age-related liver diseases.
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