Related Experiment Video
Updated: Sep 16, 2025

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Glycemic variability and iatrogenic hypoglycemia: how to resolve
Louis Monnier1, Claude Colette1, Eric Renard2
1Medical School of Montpellier, University of Montpellier, Avenue du doyen Giraud, 34093 Montpellier cedex 5, France.
Background:
Lowering plasma glucose to near normal levels without consideration of the within-day glycemic variability is a potential risk factor for iatrogenic hypoglycemia in type 1 diabetes.
Objective:
To know below which threshold the glycemic variability should be brought for minimizing or eliminating the risk of hypoglycemia in type 1 diabetes treated with SAP (Sensor Augmented Pump) or AID (Automated Insulin Delivery).
Findings:
The analysis of 38 randomized controlled trials has shown a mean reduction of 2.0 % (percentage points) in the coefficient of variation for glucose (%CV glucose) is associated with a mean decrease in the percentage of time spent with plasma glucose levels below 70 mg/dL (TBR < 70 mg/dL) of approximately 0.50 % (percentage points). In addition, the risk for hypoglycemia becomes negligible or eventually eliminated according to whether the %CV glucose is brought down below 27 or 19 %, respectively.
Conclusions:
As such thresholds are the upper limit or the averaged value of %CV glucose, respectively, in non-diabetic people, the ultimate goal to prevent hypoglycemia in people with type 1 diabetes on intensive insulin therapy should be to achieve a near normal glycemic variability. Achieving such a goal needs further improvements in insulin delivery systems.
More Related Videos
07:35Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique
Published on: January 26, 2024
06:59Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
Published on: November 13, 2016
Related Concept Videos
Hypoglycemia and Glucagon
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Diabetes Mellitus: Type 2 and Gestational
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Oral Hypoglycemic Agents: Biguanides and Glitazones