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Targeting O-GlcNAcylation in tumor-associated inflammation: From molecular mechanisms to cancer therapy

Rui Shi1, Ling Gao2, Shao-Ming Li2

  • 1Department of Oral and Maxillofacial Reconstruction, the Affiliated Hospital of Qingdao University, Qingdao 266555, China; School of Stomatology of Qingdao University, Qingdao, China; Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266555, China.

Critical Reviews in Oncology/Hematology
|July 4, 2025
PubMed

Insights

O-GlcNAcylation, a protein modification, influences cancer development. Understanding its link with inflammation offers new avenues for targeted cancer therapies and improved treatment strategies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • O-GlcNAcylation is a dynamic post-translational modification crucial in cellular signaling.
  • Dysregulation of O-GlcNAcylation is implicated in cancer progression.
  • Inflammation is a key factor in tumor development and a target for cancer intervention.

Purpose of the Study:

  • To explore the intricate mechanisms linking O-GlcNAcylation and inflammatory responses in cancer.
  • To summarize the role of O-GlcNAcylation-regulated inflammation in tumor treatment.
  • To provide a theoretical foundation for novel targeted cancer therapies.

Main Methods:

  • Literature review and synthesis of existing research on O-GlcNAcylation and cancer-related inflammation.
  • Analysis of the interplay between O-GlcNAcylation pathways and inflammatory networks in tumors.
  • Evaluation of therapeutic strategies targeting these interconnected pathways.

Main Results:

  • Imbalances in the O-GlcNAcylation cycle are critical for cancer initiation and advancement.
  • Targeting inflammation-related pathways, potentially modulated by O-GlcNAcylation, shows therapeutic promise.
  • Understanding the spatiotemporal dynamics of tumor-specific inflammation is essential for precision oncology.

Conclusions:

  • The interplay between O-GlcNAcylation and inflammation is a vital area for developing innovative cancer treatments.
  • Further research into these mechanisms can pave the way for more effective, targeted cancer therapies.
  • This review provides a basis for future clinical strategies exploiting the O-GlcNAcylation-inflammation axis in oncology.
Keywords:
InflammationO-GlcNAcylationOSCCTherapy

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