Related Experiment Video

Updated: Sep 16, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.6K

Long-term risk of ventricular arrhythmia in dilated cardiomyopathy by response to cardiac resynchronization therapy

Amine Tazibet1, Staniel Ortmans1, Charlotte Potelle1

  • 1CHU de Lille, boulevard Jules-Leclercq, 59000 Lille, France.

Archives of Cardiovascular Diseases
|July 4, 2025
PubMed

Insights

Cardiac resynchronization therapy response significantly reduces ventricular arrhythmia events in non-ischaemic dilated cardiomyopathy. Super responders show a lower risk of these events compared to partial responders, even after generator replacement.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Management

Background:

  • Advancements in pharmacological treatments and cardiac resynchronization therapy (CRT) prompt re-evaluation of implantable cardioverter defibrillators (ICDs) for non-ischaemic dilated cardiomyopathy (NI-DCM).
  • Long-term data on ventricular arrhythmia events (VAEs) based on CRT response in NI-DCM patients are limited.

Purpose of the Study:

  • To evaluate the long-term risk of VAEs stratified by CRT response in patients with NI-DCM.
  • To determine the impact of CRT response on VAE incidence in this specific patient population.

Main Methods:

  • Retrospective analysis of 192 NI-DCM patients who received CRT-defibrillator (CRT-D) for primary prevention (LVEF ≤35%, QRS duration >130ms).
  • CRT response defined as LVEF increase ≥10% to ≥35% post-implantation.
  • VAE definition included sudden arrhythmic death, sustained ventricular arrhythmia, or device-treated events.

Main Results:

  • Overall VAE incidence was 18.8% (2.9% annually) over a median follow-up of 91 months.
  • CRT response was linked to a significant 73% reduction in VAE risk (HR: 0.27).
  • Super responders demonstrated a substantially lower VAE risk than partial responders (HR: 0.06), persisting post-generator replacement.

Conclusions:

  • CRT response is a critical factor in mitigating VAE risk for NI-DCM patients receiving CRT-D.
  • Super responders to CRT experience significantly fewer VAEs than partial responders.
  • The protective effect of super-response against VAEs is maintained even after device generator replacement.
Abstract

Keywords:
Cardiac resynchronization therapyDilated cardiomyopathyGenerator replacementHeart failureVentricular arrhythmia

More Related Videos

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

956
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.2K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
30
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
38
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
61
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
39
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
1.3K
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
61