Related Experiment Video

Updated: Sep 16, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.4K

Association between lipoprotein(a) concentration and outcomes after percutaneous coronary intervention: A systematic

Gianmarco Cancelli1, Camilla S Rossi1, Ovidio De Filippo2

  • 1Department of Cardiothoracic Surgery, Weill Cornell Medicine, 10065 New York, USA.

Archives of Cardiovascular Diseases
|July 4, 2025
PubMed

Insights

Elevated lipoprotein(a) levels significantly increase risks for cardiovascular events and death after percutaneous coronary intervention. This meta-analysis confirms high lipoprotein(a) is a key predictor of adverse outcomes in these patients.

Area of Science:

  • Cardiology
  • Biomarkers
  • Interventional Cardiology

Background:

  • Lipoprotein(a) is a known risk factor for cardiovascular disease.
  • Elevated lipoprotein(a) may predict poor outcomes after percutaneous coronary intervention (PCI).

Purpose of the Study:

  • To conduct a meta-analysis evaluating clinical outcomes in patients undergoing PCI, stratified by lipoprotein(a) concentration.
  • To compare outcomes between high and low serum lipoprotein(a) groups post-PCI.

Main Methods:

  • Systematic literature search of Ovid MEDLINE, EMBASE, and Cochrane Library.
  • Included 14 studies with 40,241 patients undergoing PCI, stratified by preoperative lipoprotein(a) levels.
  • Primary outcome: all-cause death. Secondary outcomes: myocardial infarction, cardiovascular death, MACE, and stroke.

Main Results:

  • High lipoprotein(a) was associated with significantly increased rates of all-cause death (IRR 1.42), myocardial infarction (IRR 1.45), cardiovascular death (IRR 1.50), MACE (IRR 1.35), and stroke (IRR 1.33).
  • Mean follow-up was 4.9 years.
  • Analyses remained consistent in sensitivity tests.

Conclusions:

  • High lipoprotein(a) concentrations are linked to worse clinical outcomes in patients treated with PCI.
  • This highlights lipoprotein(a) as a critical prognostic marker in interventional cardiology.
Abstract

Keywords:
Coronary artery diseaseLipoprotein(a)Percutaneous coronary intervention

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.4K
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.5K

Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
35
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
38
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
41
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
63
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
38
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
298