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Relationship between plasma atherogenic index and thyroid function: evidence from NHANES 2007-2012
Tianshu Li1,2, Chunqiu Liu1,2, Haoran Zhou3
1Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Scientific Reports
|July 4, 2025
Summary
Higher plasma atherogenic index (AIP) in US adults is linked to altered thyroid function, specifically increasing TSH and FT3, while decreasing FT4. Total T3 and T4 show complex nonlinear relationships with AIP.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Public Health
Background:
- Thyroid function is linked to metabolic disorders and blood lipid levels.
- The relationship between plasma atherogenic index (AIP) and thyroid function remains unexplored.
Purpose of the Study:
- To investigate the association between plasma atherogenic index (AIP) and thyroid function levels.
- Utilize data from the National Health and Nutrition Examination Survey (NHANES) for this analysis.
Main Methods:
- Analysis of 8365 non-pregnant adults from the 2007-2012 NHANES database.
- Calculation of AIP using log10 (triglycerides/HDL cholesterol).
- Weighted linear regression models and restricted cubic spline plots were employed to assess relationships.
Main Results:
- Higher AIP was linearly positively correlated with TSH (Thyroid-Stimulating Hormone).
- Higher AIP was linearly negatively correlated with FT4 (Free Thyroxine).
- Higher AIP showed nonlinear positive correlation with FT3 (Free Triiodothyronine) and an inverted U-shaped correlation with TT3 (Total Triiodothyronine) and TT4 (Total Thyroxine).
Conclusions:
- Plasma atherogenic index (AIP) is associated with thyroid function in US adults.
- These findings highlight a complex interplay between lipid metabolism and thyroid status.
- Further research may elucidate the clinical implications of these associations.
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