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Updated: Sep 16, 2025

Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
Published on: April 18, 2025
Knowledge mapping of micro/nanomotors in cancer treatment: a bibliometric analysis (2006-2025)
Ying Song1, Kai Zhao2, Yan Yang1
1Department of Pharmacy, Shengli Oilfield Central Hospital, Dongying, 257034, Shandong, China.
Background:
Malignant tumors present challenges such as high heterogeneity and the limitations of traditional therapies, driving innovations in nanomedicine, particularly in the development of micro/nanomotors. These autonomous devices offer superior tumor penetration capabilities but and lack systematic bibliometric insights.
Method:
Data from WoSCC (2006-2025) were analyzed using bibliometric tools (CiteSpace, VOSviewer, and "bibliometrics") to map research landscapes.
Results:
A total of 10,609 articles from 38 countries were identified, with annual output growing at a compound annual growth rate (CAGR) of 22% and peaking at 126 articles in 2024. China led globally with 380 publications (62.4%). The Chinese Academy of Sciences (123 articles) emerged as the leading institution in this domain, while ACS NANO (36 articles) was identified as the most prolific and co-cited journal. Wang J contributed the highest number of articles, and publications by Wang J also exhibited the highest co-citation frequency. The keyword "penetration" exhibited the strongest citation burst (2021-2025), reflecting breakthroughs in overcoming tumor physical barriers.
Conclusion:
This study highlights China's dominance, rapid technological evolution toward intelligent actuation and immunotherapy integration, and "penetration" as a pivotal frontier. Findings provide strategic guidance for future research and clinical translation.
Insights
This bibliometric analysis reveals China
Area of Science:
- Nanomedicine
- Biomedical Engineering
- Cancer Therapy
Background:
- Malignant tumors present challenges due to heterogeneity and limitations of traditional therapies.
- Nanomedicine, especially micro/nanomotors, offers advanced tumor penetration capabilities.
- Systematic bibliometric insights into nanomotor research for cancer are lacking.
Purpose of the Study:
- To conduct a bibliometric analysis of micro/nanomotor research in nanomedicine.
- To map the research landscape, identify key contributors, and analyze trends.
- To provide strategic guidance for future research and clinical translation.
Main Methods:
- Bibliometric analysis of 10,609 articles published between 2006 and 2025.
- Data sourced from the Web of Science Core Collection (WoSCC).
- Analysis performed using CiteSpace, VOSviewer, and bibliometric methods.
Main Results:
- China leads global research output with 380 publications (62.4%).
- The Chinese Academy of Sciences and ACS NANO are leading institutions and journals, respectively.
- The keyword 'penetration' shows a strong citation burst (2021-2025), indicating progress in overcoming tumor barriers.
Conclusions:
- China dominates nanomotor research for cancer therapy.
- Research is rapidly evolving towards intelligent actuation and immunotherapy integration.
- Tumor penetration remains a pivotal research frontier for nanomedicine.
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