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Fast and High-Resolution luminal water imaging for prostate cancer diagnosis
Hao Li1,2, Nikita Sushentsev2, Dimitri Kessler2
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, People's Republic of China.
Magnetic Resonance in Medicine
|July 5, 2025
Summary
This study introduces TEMPURA, an accelerated MRI method that significantly reduces acquisition time for luminal water imaging (LWI) in prostate cancer detection. TEMPURA maintains high diagnostic performance, offering a faster, more efficient noninvasive imaging solution.
Area of Science:
- Magnetic Resonance Imaging (MRI)
- Medical Imaging Physics
- Prostate Cancer Diagnostics
Background:
- Luminal water imaging (LWI) is a promising noninvasive MRI technique for prostate cancer detection and grading.
- A key limitation of LWI is its long acquisition time, hindering clinical applicability.
- Accelerated imaging techniques are crucial for improving the efficiency of LWI.
Purpose of the Study:
- To implement and evaluate an accelerated multi-echo spin-echo method, T2 mapping using echo merging plus k-t undersampling with reduced flip angles (TEMPURA), for LWI.
- To address the limitation of long acquisition times in LWI for prostate cancer assessment.
- To assess the diagnostic performance of the accelerated LWI method.
Main Methods:
- A prospective study involving 24 patients with biopsy-proven prostate cancer was conducted on a 3T MRI system.
- Two TEMPURA-based LWI sequences (Fast and High-Resolution) were compared against a standard LWI sequence.
- Luminal water fraction and other parameters were analyzed using correlation, Bland-Altman plots, and ROC analysis.
Main Results:
- The Fast TEMPURA sequence reduced acquisition time from 8.3 to 2.8 minutes; High-Resolution reduced it to 5.4 minutes while doubling spatial resolution.
- Both Fast and HR TEMPURA sequences demonstrated high correlation (r=0.90-0.97) and low bias for luminal water fraction compared to the standard sequence.
- No significant differences in diagnostic performance (AUC values) were observed between TEMPURA sequences and the standard method.
Conclusions:
- TEMPURA significantly reduces LWI acquisition time and enhances spatial resolution.
- The accelerated TEMPURA method provides accurate LWI measurements and maintains diagnostic performance for malignant lesion detection.
- TEMPURA offers a faster and efficient alternative for noninvasive prostate cancer imaging.
