Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Depressive behavior and hyperactive adrenocortical function.

J H Kocsis, J M Davis, M M Katz

    The American Journal of Psychiatry
    |November 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Obesity, but not metabolic syndrome, negatively affects outcome in bipolar disorder.

    Acta psychiatrica Scandinavica·2015
    Same author

    ABCB1 (MDR1) predicts remission on P-gp substrates in chronic depression.

    The pharmacogenomics journal·2014
    Same author

    Susceptibility to a parkinsonian toxin varies during primate development.

    Experimental neurology·2012
    Same author

    Impact of methamphetamine on dopamine neurons in primates is dependent on age: implications for development of Parkinson's disease.

    Neuroscience·2011
    Same author

    Aged monkeys as a partial model for Parkinson's disease.

    Pharmacology, biochemistry, and behavior·2011
    Same author

    Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6.

    Gene therapy·2009
    Same journal

    2026 Annual Meeting: President-Elect Address.

    The American journal of psychiatry·2026
    Same journal

    2026 Annual Meeting: CEO and Medical Director's Address.

    The American journal of psychiatry·2026
    Same journal

    Reports to the Membership.

    The American journal of psychiatry·2026
    Same journal

    Convergent Metabolic Dysregulations But Divergent Contributing Pathways Across Severe Mental Disorders: The Power of Combining Genetics and Metabolomics.

    The American journal of psychiatry·2026
    Same journal

    2026 Annual Meeting: Presidential Address.

    The American journal of psychiatry·2026
    Same journal

    Represcribing Previously Used Antipsychotics: Response to So.

    The American journal of psychiatry·2026
    See all related articles

    Depression subtypes showed limited links to hypothalamic-pituitary-adrenocortical (HPA) function. However, HPA overactivation in depressed patients correlated with anxiety, sleep, and psychomotor disturbances.

    Area of Science:

    • Neuroendocrinology
    • Psychiatry
    • Clinical Psychology

    Background:

    • The hypothalamic-pituitary-adrenocortical (HPA) axis is implicated in depression.
    • Previous research suggests varied HPA function across depressive subtypes.

    Purpose of the Study:

    • To investigate the relationship between depressive subtypes, clinical-behavioral features, and HPA axis function.
    • To identify specific patient profiles associated with HPA axis dysregulation in hospitalized depressed individuals.

    Main Methods:

    • Examined 132 hospitalized depressed patients.
    • Assessed pre- and postdexamethasone plasma cortisol levels.
    • Correlated endocrine measures with clinical-behavioral characteristics like anxiety and psychomotor disturbance.

    Related Experiment Videos

    Main Results:

    • Significant positive correlations were found between cortisol measures and anxiety, psychomotor disturbance, distressed expression, and sleep disturbance.
    • Few relationships were observed between illness severity and HPA function.
    • No significant endocrine differences were identified between endogenous/nonendogenous or psychotic/nonpsychotic subtypes.

    Conclusions:

    • Suggests a profile of depressed patients with HPA overactivation.
    • This profile is characterized by anxiety, sleep and psychomotor disturbances, weight loss, and older age.
    • HPA axis dysregulation may be a common feature in certain presentations of depression, irrespective of subtype.