Related Experiment Video

Updated: Sep 16, 2025

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines
07:49

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines

Published on: March 17, 2023

2.6K

Mitochondrial homeostasis and their impact on gastric carcinoma

Amrutha Arjunan1, Ganesh Venkatraman2, Leena Dennis Joseph3

  • 1Department of Biomedical Sciences, Sri Ramachandra Faculty of Biomedical Sciences &Technology Sri Ramachandra Institute of Higher Education and Research, Chennai 600116, India.

The International Journal of Biochemistry & Cell Biology
|July 5, 2025
PubMed

Insights

Mitochondrial dysfunction fuels gastric cancer development by impairing energy production and increasing oxidative stress. Understanding these mitochondrial changes is key for new gastric cancer diagnostics and therapies.

Area of Science:

  • Oncology and Molecular Biology: Focuses on the intricate role of mitochondria in gastric cancer.

Background:

  • Gastric cancer is a leading cause of death globally.
  • Mitochondrial dysfunction is a key driver of gastric tumor development, promoting metabolic changes, resistance to apoptosis, and metastasis.

Purpose of the Study:

  • To review and elucidate the altered mitochondrial functionalities in gastric cancer.
  • To highlight the role of mitochondrial homeostasis in gastric carcinogenesis.

Main Methods:

  • This review synthesizes current research on mitochondrial alterations in gastric cancer.
  • Analysis of molecular mechanisms including mitochondrial DNA, respiratory chain complexes, and epigenetic factors.

Main Results:

  • Dysregulated mitochondrial functions contribute to metabolic reprogramming and therapeutic resistance in gastric cancer.
  • Aberrations in mitochondrial components create a pro-tumorigenic microenvironment, enhancing tumor progression.

Conclusions:

  • Understanding mitochondrial intricacies in gastric cancer is crucial for developing novel diagnostic and therapeutic strategies.
  • Further research into mitochondrial homeostasis may lead to definitive interventions for gastric cancer growth.
Keywords:
Gastric cancerHelicobacter pyloriMetabolic homeostasisMitochondriaMitochondria-targeted drug therapyMtDNA mutations

More Related Videos

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.2K
Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

859

Related Concept Videos

Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
12.4K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
15.1K
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
15.1K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
8.1K
The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
3.7K