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Serositis Associated with Chronic Graft-Versus-Host Disease
Te Bs Chloe1, Elahi Bs Taara1, Samples Kenna1
1Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington.
Transplantation and Cellular Therapy
|July 5, 2025
Summary
Serositis, a complication of chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic cell transplantation (HCT), can significantly impact patients. This study highlights its occurrence, management, and survival outcomes, emphasizing the need for further research.
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- Serositis is a known complication of chronic graft-versus-host disease (cGVHD).
- It occurs in patients following allogeneic hematopoietic cell transplantation (HCT).
- Limited data exist on cGVHD-associated serositis, including patient demographics, incidence, risk factors, and management.
Purpose of the Study:
- To describe the patient population, incidence, risk factors, and management strategies for cGVHD-associated serositis.
- To analyze clinical outcomes and survival associated with serositis post-HCT.
Main Methods:
- Retrospective analysis of 50 adult patients who underwent HCT and developed cGVHD-associated serositis.
- Data collected from Fred Hutchinson Cancer Center between 1998 and 2021.
- Review of patient demographics, serositis types (pleural and pericardial effusions), management, recurrence, and survival.
Main Results:
- Most common manifestations were pericardial effusions (n=31) and pleural effusions (n=38).
- Medical management was utilized in 94% for pleural and 87% for pericardial effusions.
- Eleven patients experienced recurrent serositis.
- Median overall survival at 1-year post-diagnosis was 86%, and 69% at 3-years.
Conclusions:
- Serositis is a serious, atypical manifestation of cGVHD.
- Further prospective studies with larger cohorts are needed to optimize treatment strategies and improve outcomes.
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