Related Experiment Video
Updated: Sep 16, 2025

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
Published on: November 1, 2019
SHMT proteins: An emerging set of serine hydroxymethyltransferase in cancer
Rong Fu1, Fulin Sun1, Wenbo Wang2
1Department of Genetics and Cell Biology, School of Basic Medicine, Qingdao University, Qingdao 266071, China; Department of Oncology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Abstract:
Serine hydroxy methyltransferase (SHMT) exists in a homotetramer form and is influenced by nucleic acids, proteins, and other small molecules. Its feature is that it can catalyze the production of 5,10-methylenetetrahydrofolate (5, 10-CH2-THF), and 5,10-CH2-THF is a source of one‑carbon units. It is of great significance in nucleic acid synthesis and providing methyl. A large number of studies have confirmed that SHMT regulates a series of life activities such as proliferation, invasion, migration, and apoptosis of tumor cells. Therefore, the research on abnormal expression of SHMT in tumor cells has profound significance for the diagnosis and treatment of cancer. This article reviews the structure, biological process, markers, and related drug treatment of SHMT protein, providing new ideas for the diagnosis and treatment of tumors.
Related Concept Videos
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Abnormal Proliferation
Mismatch Repair
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Phosphorylation
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
PI3K/mTOR/AKT Signaling Pathway
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....

