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AIRWEIGHS: A Randomized Controlled Trial of Air Cleaners in Normal Weight and Overweight/Obese Children With Asthma

Anna Y Qiu1, Emily P Brigham2, Han Woo1

  • 1Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

The Journal of Allergy and Clinical Immunology. in Practice
|July 5, 2025
PubMed

Insights

Air cleaners reduced indoor air pollution for children with asthma, but did not improve asthma symptoms or outcomes, regardless of weight status. This study highlights the need for further research into effective asthma management strategies.

Area of Science:

  • Environmental Health
  • Pediatric Asthma
  • Air Pollution Research

Background:

  • Overweight and obesity are linked to increased asthma severity in children.
  • These children may be more vulnerable to the effects of air pollution.

Purpose of the Study:

  • To investigate if air cleaner interventions reduce indoor air pollution more effectively in overweight/obese children with asthma compared to normal-weight children.
  • To assess the differential impact of reduced indoor air pollution on asthma outcomes between these two groups.

Main Methods:

  • The AIRWEIGHS trial was a randomized, placebo-controlled study involving children with asthma.
  • Participants received either a functional air cleaner or a placebo device for 12 weeks.
  • Asthma symptoms, lung function, and home air pollution levels were measured.

Main Results:

  • Air cleaners significantly reduced ultrafine particles (UFP), PM2.5, PM10, and NO2 levels.
  • Despite effective pollution reduction, no improvements were observed in primary or secondary asthma outcomes.
  • No significant differences in outcomes were found between normal-weight and overweight/obese children.

Conclusions:

  • Portable air cleaners are effective at reducing indoor air pollution.
  • However, this intervention did not yield observable benefits for asthma outcomes in children, irrespective of weight status.
Abstract

Keywords:
Air filterAir pollutantsAsthmaControlled clinical trialEnvironmentPediatric obesity

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