Neutrophil Extracellular Trap (NET) Markers in Psoriasis: Linking With Disease Severity and Comorbidities

Psoriatic patients have shown higher levels of neutrophil extracellular traps (NETs) vs healthy controls. Psoriasis is often associated with other comorbidities such as cardiovascular disease. An increase in indirect markers of NETs has been found in patients with increased cardiovascular events in patients without psoriasis. We conducted a prospective observational study with psoriatic patients. A total of 39 of patients were included. Myeloperoxidase, neutrophil elastase and double-stranded DNA were significantly higher in patients with severe-to-moderate vs mild psoriasis. Myeloperoxidase was also significantly higher in patients of moderate high vs low cardiovascular risk (p=.01) in patients with mild psoriasis. Patients with psoriatic arthritis show higher myeloperoxidase levels higher vs those without arthritis (p=.048). Myeloperoxidase was also significantly correlated (p=.0375) with the patients' BMI. The detection of NETs through indirect markers (myeloperoxidase, neutrophil elastase and double-stranded DNA) is associated with the severity of psoriasis. In addition, myeloperoxidase can be useful in psoriatic patients as biomarkers of comorbidities.