Erythema Papulatum Centrifugum: A Clinically Distinct Dermatosis. CLINI-AEDV Case Series

Erythema papulatum centrifugum is a rare condition marked by a centrifugally growing border dotted with small papules and a relapsing course, often worse in spring and summer. There aren't any specific diagnostic tests to confirm it. This study analyzes the clinical characteristics of seven cases, representing the largest series of non-Oriental patients to date. Our findings confirm the pruritic and seasonally relapsing nature of this condition. Lesions are typically few, primarily located on the trunk, and generally exceed 5cm in diameter. Interestingly, in one patient, two outbreaks correlated temporally with the COVID-19 vaccine. In two other cases, the condition was linked to hematological malignancies: multiple myeloma and Hodgkin lymphoma. These observations, along with other neoplasm-associated cases reported in the literature, suggest that this entity might function as a paraneoplastic syndrome.