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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
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[Hormone therapy in the adjuvant setting based on risk assessment]
Julie Cabal1, Céline Lescure1, Véronique Dieras1
1CLCC Eugène-Marquis, Rennes, France.
Bulletin Du Cancer
|July 5, 2025
Summary
Adjuvant hormone therapy for early-stage HR+ breast cancer depends on recurrence risk. High-risk patients may benefit from intensified treatment, including ovarian suppression, guided by studies like OlympiA, monarchE, and NATALEE.
Area of Science:
- Oncology
- Endocrinology
- Genetics
Context:
- Early-stage hormone receptor-positive (HR+) breast cancer management.
- Recurrence risk assessment is crucial for treatment personalization.
- Adjuvant endocrine therapy is standard for HR+ disease.
Purpose:
- Review current strategies for adjuvant hormone therapy in HR+ breast cancer.
- Discuss the role of ovarian suppression in managing high-risk patients.
- Analyze key clinical trials (OlympiA, monarchE, NATALEE) influencing treatment decisions.
Summary:
- Hormone therapy is vital for early-stage HR+ breast cancer.
- Risk stratification guides treatment de-escalation or intensification.
- Ovarian suppression is an emerging consideration for high-risk tumors.
Impact:
- Informs clinical practice for tailoring adjuvant therapy in breast cancer.
- Highlights the importance of ongoing research and clinical trials.
- Aids in personalizing breast cancer treatment based on risk stratification.
Keywords:
Adjuvant hormone therapyBiomarkersBiomarqueursCancer du sein RH+HR+ breast cancerHormonothérapie adjuvanteRisk stratificationStratification des risquesTargeted therapiesThérapies cibléesMore Related Videos
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