H3Africa: a model for implementing biobank-based genomic research in resource-constrained settings

Area of Science:

• Genomics and Global Health
• Bioinformatics and Data Science
• Health Disparities Research

Background:

• The Human Heredity and Health in Africa (H3Africa) consortium was established in 2012 to address the need for African-led genomic research.
• Limited infrastructure, resources, and expertise in Africa hindered large-scale genomic research projects.
• A key challenge was the underrepresentation of African populations in global complex trait genetics studies.

Purpose of the Study:

• To review the major contributions of H3Africa to omics research in Africa.
• To highlight the development of a sustainable research enterprise within the continent.
• To showcase H3Africa as a template for transnational omics research in resource-constrained environments.

Main Methods:

• Establishment of DNA biorepositories and a Pan-African bioinformatics network (H3ABioNet).
• Development of ethical and legal guidelines for genomic research.
• Capacity building through PhD support, training, and workshops for over 500 researchers across 30 African countries.

Main Results:

• H3Africa supported 480 PhD graduates and 467 trainees, conducted over 200 workshops, and led to over 700 publications.
• Significant advancements in omics research relevant to African populations.
• Sustained core resources, new datasets, publications, and collaborations beyond formal funding.

Conclusions:

• H3Africa successfully fostered a sustainable, African-led genomic research ecosystem.
• The consortium's model provides a valuable template for conducting transnational omics research in resource-limited settings.
• Continued generation of data and collaborations ensures the legacy of H3Africa in global health research.