Multifunctional Hydrogel Adhesive Accelerates Hemostasis and Wound Healing with Combined Programmatic Photothermal...

Recent advances in bioadhesives offer promising solutions to the critical issue of uncontrolled bleeding in medical scenarios, with their rapid and strong tissue adhesion properties facilitating effective hemostasis and potentially easing the economic burden on healthcare systems. In this context, we present the design, formation, and characterization of a versatile bioadhesive hydrogel comprising polydopamine nanoparticles (PDA-NPs), poly(vinyl alcohol) (PVA), and a phenylboronic acid derivative. This adhesive, boasting profound adhesion to the surface of biological tissues, not only adheres to and aggregates erythrocytes and platelets but also effects high temperature through near-infrared (NIR) light photothermal transduction, thereby accelerating the coagulation cascade, markedly enhancing the efficacy of hemostasis. Subsequently, a mild low temperature is regulated via photothermal therapy to foster cellular migration and angiogenesis, expediting wound healing, which establishes a programmed hemostasis and healing-augmenting photothermal therapy system. Moreover, this adhesive also exhibits the capacity to neutralize reactive oxygen species (ROS) and excellent biocompatibility. Overall, the adhesive manifests robust bioadhesive properties, superior hemostatic attributes, and the capacity to neutralize ROS while actively fostering cutaneous incision healing. As such, it holds considerable promise for applications within emergency hemostasis and wound care adjuncts.