Related Experiment Video
Updated: Sep 16, 2025
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Coordination complexes of lanthanide(III) derived from 2-(pyridin-2-yl)-1H-benzo[d]imidazole (bimpy) and
Luis E Romero-Gutiérrez1, Miguel A Vergara-Rodríguez1, J Antonio Cruz-Navarro1
1Facultad de Ciencias Químicas, Universidad Veracruzana, Prolongación de Oriente 6, No. 1009, C.P. 94340 Orizaba, Veracruz, Mexico.
Abstract:
Seven novel coordination complexes (1-7) derived from trivalent lanthanides (La, Nd, Sm, Eu, Gd, Tb, Dy) and bidentate ligands 2,2'-bipyridine (bpy) and 2-(pyridin-2-yl)-1H-benzo[d]imidazole (bimpy) were synthesised. A series of analytical and spectroscopic techniques, including high-resolution mass spectrometry, unambiguously characterised all complexes. Using ligand mixtures to obtain coordination complexes with anticancer activity has shown promising results. Therefore, additional experiments were performed to evaluate the cytotoxic activity in non-transformed cells (NIH/3 T3 and J774A.1) and transformed cells (HeLa, Caco-2 and MCF-7), as well as erythrocyte lysis experiments in human red blood cells. The results revealed moderate but selective cytotoxicity against the studied cell lines. Additional PBE0/def2-SVP computational studies were carried out to elucidate the coordination number, geometry and structural organisation in agreement with the experimental data.
More Related Videos
07:24Hyperspectral Imaging as a Tool to Study Optical Anisotropy in Lanthanide-Based Molecular Single Crystals
Published on: April 14, 2020
13:21Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Related Concept Videos
02:42Valence Bond Theory
03:02Colors and Magnetism
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
02:51Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
00:43Complexometric Titration: Ligands
02:34Structural Isomerism
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
01:22EDTA: Chemistry and Properties