RONS clearing TePt @ sodium carboxymethyl cellulose nanozymes for chronic enteritis therapy
Xinyan Hu1, Gongxin Zhang1, Lida Tang1
1State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, National & Local Joint Engineering Research Center of Preparation Technology of Nanomaterials, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
International Journal of Biological Macromolecules
|July 6, 2025
Summary
New TePt nanorods effectively scavenge reactive oxygen and nitrogen species, treating chronic enteritis by restoring redox balance and promoting gut repair in mice without adverse effects.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Chronic enteritis involves reactive oxygen and nitrogen species (RONS) disrupting cellular redox homeostasis, leading to tissue damage.
- Targeted RONS removal is a promising therapeutic strategy for chronic enteritis.
- Developing novel antioxidant nanozymes is crucial for effective enteritis treatment.
Purpose of the Study:
- To develop TePt nanorods (TP) with antioxidant properties for chronic enteritis treatment.
- To evaluate the efficacy of TP in scavenging RONS and protecting cells from oxidative stress.
- To assess the therapeutic potential of TP in a DSS-induced mouse model of chronic enteritis.
Main Methods:
- Synthesis and characterization of TePt nanorods (TP).
- Evaluation of TP's pH-dependent enzymatic activities (superoxide dismutase and catalase).
- In vitro assessment of TP's ability to scavenge intracellular RONS and protect cells.
- In vivo study using a dextran sulfate sodium (DSS)-induced mouse model of chronic enteritis.
Main Results:
- TP exhibited pH-dependent SOD and catalase activities, effectively scavenging RONS under neutral conditions.
- TP protected cells from oxidative stress-induced damage by eliminating intracellular RONS.
- Intragastric administration of TP significantly inhibited proinflammatory cytokine expression in DSS-induced enteritis mice.
- TP restored redox homeostasis and promoted bowel repair without noticeable adverse effects.
Conclusions:
- TePt nanorods are effective antioxidant nanozymes for treating chronic enteritis.
- TP demonstrates significant therapeutic potential by reducing inflammation and promoting tissue repair.
- This study offers novel insights into designing nanozymes for inflammatory bowel disease treatment.
Related Concept Videos
01:20Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
321
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
321
01:21Drugs for Treatment of Constipation-Predominant IBS
350
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
350
01:29Drugs for Treatment of Ulcerative Colitis in IBD
242
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
242
01:17Chronic Bowel Disorders: Introduction
541
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
541
01:17Drugs for Treatment of Diarrhea-Predominant IBS
308
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
308