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Plasmonic surgery: SERS-active smart nanotools reshaping intraoperative decision-making and precision therapy
Biqing Chen1, Jiayin Gao1, Haizhu Sun1
1Gynaecology and Obstetrics, The Second Affiliated Hospital of Harbin Medical University, Harbin Medical University, Heilongjiang 150081, PR China.
Critical Reviews in Oncology/Hematology
|July 6, 2025
Summary
Surface-enhanced Raman scattering (SERS) technology, or plasmonic surgery, overcomes traditional surgical limitations in tumor margin detection. Intelligent nanoplatforms enable real-time molecular boundary alerts for enhanced precision surgery.
Area of Science:
- Nanotechnology
- Surgical Oncology
- Biomedical Engineering
Background:
- Traditional surgery faces limitations in accurately detecting tumor margins, leading to missed detections.
- Intraoperative frozen pathology is time-consuming, causing delays in surgical decision-making.
Purpose of the Study:
- To review how surface-enhanced Raman scattering (SERS) active intelligent nanoplatforms are transforming intraoperative decision-making.
- To highlight advancements in SERS technology for precision surgery.
Main Methods:
- Systematic elucidation of SERS-active nanoplatforms for molecular detection and therapy.
- Discussion of self-navigating nanorobots and stimulus-responsive probes.
- Integration of SERS with augmented reality navigation systems.
Main Results:
- SERS enables real-time tumor margin delineation and intraoperative molecular boundary alerts.
- A closed-loop workflow from preoperative enrichment to postoperative validation is demonstrated.
- Ethical considerations and future directions for SERS-guided surgery are explored.
Conclusions:
- SERS technology, or plasmonic surgery, offers revolutionary solutions to surgical limitations.
- Advancements in SERS nanoplatforms are paving the way for next-generation precision surgery.
- Interdisciplinary collaboration is crucial for translating SERS from research to clinical practice.
