Related Experiment Video

Updated: May 8, 2026

Assessment of Cardiac Function and Energetics in Isolated Mouse Hearts Using 31P NMR Spectroscopy
11:38

Assessment of Cardiac Function and Energetics in Isolated Mouse Hearts Using 31P NMR Spectroscopy

Published on: August 31, 2010

26.4K

Evaluation of Anthracycline-Induced Cardiotoxicity Using Proton Magnetic Resonance Spectroscopy Compared With Cardiac

Yulin Tu1, Xing-Yuan Kou1, Jinrong Zhou2

  • 1Department of Radiology, The Affiliated Hospital of Southwest Medical University.

Circulation Journal : Official Journal of the Japanese Circulation Society
|July 6, 2025
PubMed
Abstract

Insights

Proton magnetic resonance spectroscopy (¹H-MRS) detected increased Lipid1 levels at 6 weeks, enabling earlier diagnosis of anthracycline-induced cardiotoxicity (AIC) than traditional ejection fraction measurements.

Area of Science:

  • Cardiology
  • Oncology
  • Biomedical Imaging

Background:

  • Anthracycline-induced cardiotoxicity (AIC) is a severe complication limiting chemotherapy.
  • Current diagnostic methods for AIC lack sensitivity, necessitating improved early detection strategies.

Purpose of the Study:

  • To evaluate the potential of cardiac magnetic resonance (CMR) and proton magnetic resonance spectroscopy (¹H-MRS) for early detection of AIC.
  • To identify early biomarkers of AIC using ¹H-MRS.

Main Methods:

  • A prospective animal study involving 20 rabbits treated with adriamycin.
  • Weekly adriamycin administration with bi-weekly CMR and ¹H-MRS assessments.
  • Linear mixed models and ROC analysis to determine diagnostic thresholds and timing.

Main Results:

  • Lipid1 levels significantly increased at week 6, preceding the decrease in left ventricular ejection fraction (LVEF) at week 8.
  • A Lipid1 cutoff of 2.60 demonstrated high diagnostic accuracy (AUC=0.745) for AIC at week 6.
  • Lipid1 showed a moderate negative correlation with LVEF (r=-0.418).

Conclusions:

  • ¹H-MRS-detected Lipid1 increase serves as an early indicator of AIC.
  • This method offers a more sensitive approach for early AIC diagnosis compared to LVEF assessment.
Keywords:
CardiotoxicityLipidsMagnetic resonance imagingProton magnetic resonance spectroscopy

More Related Videos

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model14:24

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Published on: January 21, 2018

11.8K
A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

4.8K

Related Concept Videos

The Periodic Table and Organismal Elements01:27

The Periodic Table and Organismal Elements

Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...