Sex differences and age-related changes of large-scale brain networks
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View abstract on PubMed
Summary
This summary is machine-generated.Males exhibit stronger inter-network brain connectivity, while females show enhanced intra-network connectivity. Age impacts female inter-network connectivity more, with both sexes showing reduced intra-network connectivity over time.
Area Of Science
- Neuroscience
- Brain Imaging
- Human Neurobiology
Background
- Previous research indicates sex differences in brain structure and function.
- However, large-scale brain network-level sex and age differences are not well understood.
Purpose Of The Study
- To investigate sex differences in large-scale brain network connectivity.
- To examine age-related changes in brain network connectivity in males and females.
Main Methods
- Resting-state functional MRI data from 436 healthy adults were analyzed.
- Independent component analysis identified large-scale brain networks.
- Multivariate analyses explored sex differences in inter- and intra-network functional connectivity (FC) and their relationship with age.
Main Results
- Males showed stronger inter-network FC; females exhibited stronger intra-network FC in key networks.
- Females displayed greater age-related decline in inter-network FC compared to males.
- Most intra-network FC decreased with age in both sexes, with some exceptions.
Conclusions
- Males generally possess stronger inter-network connectivity, females stronger intra-network connectivity.
- Age-related declines in inter-network connectivity are more pronounced in females.
- This study provides insights into sex- and age-dependent brain network organization.
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