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Updated: Sep 16, 2025

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
Published on: April 12, 2024
Imaging and pulmonary function techniques in ARDS diagnosis and management: current insights and challenges
Denise Battaglini1,2, Marcus J Schultz3,4,5,6, Gustavo A Cortes Puentes7
1Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, Genova, Italy.
Diagnosing and managing Acute Respiratory Distress Syndrome (ARDS) requires personalized approaches. Integrating advanced lung imaging with functional assessments can improve diagnostic accuracy and tailor treatments for better patient outcomes.
Area of Science:
- Critical Care Medicine
- Pulmonology
- Medical Imaging
Background:
- Acute Respiratory Distress Syndrome (ARDS) presents diagnostic and management challenges due to its heterogeneity.
- Individualized care is crucial for improving patient outcomes in ARDS.
- Current diagnostic and therapeutic strategies for ARDS require enhancement.
Purpose of the Study:
- To explore the integration of advanced lung imaging and functional parameters for enhanced ARDS diagnosis.
- To highlight the potential of personalized therapy based on ARDS subphenotypes.
- To identify future research directions for optimizing ARDS management.
Main Methods:
- Review of advanced lung imaging techniques (CT, ultrasound, EIT).
- Assessment of functional parameters (compliance, driving pressure, mechanical power).
- Discussion of integrating imaging with functional data for diagnostic precision.
Main Results:
- Advanced imaging and functional parameters offer insights into respiratory mechanics and ARDS severity.
- Integration of these techniques shows promise for enhancing diagnostic accuracy.
- Variability in interpretation necessitates standardized validation of methodologies.
Conclusions:
- Personalized management strategies for ARDS can be advanced by integrating imaging and functional assessments.
- Tailored mechanical ventilation strategies based on ARDS subphenotypes may improve outcomes.
- Future research should focus on AI, innovative technologies, and data integration for ARDS.
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