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Gut Microbiota-induced Long Non-coding RNA Snhg9 Regulates the Development of Human Malignant Tumors

Dengke Jia1,2,3, Yaping He4, Qianle Chen1,2,3

  • 1Second Clinical Medical College, Lanzhou University, Lanzhou, 730000, China.

Current Molecular Medicine
|July 7, 2025
PubMed

Insights

Gut microbes and long non-coding RNAs (lncRNAs) impact cancer progression. Specifically, lncRNA Snhg9 interacts with gut microbiota, influencing human malignant tumors and offering potential therapeutic targets.

Area of Science:

  • Oncology
  • Microbiology
  • Molecular Biology

Background:

  • Gut microbes modulate cancer development via immune and metabolic pathways.
  • Long non-coding RNAs (lncRNAs) are implicated in cancer progression and are influenced by intestinal microbiota.
  • Specific lncRNA Snhg9 exhibits interactions with gut microorganisms relevant to human malignancies.

Purpose of the Study:

  • To investigate the intricate relationship between lncRNAs and intestinal flora in cancer.
  • To elucidate the regulatory mechanisms of lncRNA Snhg9 in the context of human malignant tumors.
  • To identify novel therapeutic targets for human cancers based on lncRNA-microbiota interactions.

Main Methods:

  • Literature review and analysis of existing research on lncRNAs, gut microbiota, and cancer.
  • Bioinformatic analysis to identify cross-talk between Snhg9 and microbial communities.
  • Molecular pathway analysis to understand the role of Snhg9 in tumor progression.

Main Results:

  • Established a significant cross-talk between lncRNA Snhg9 and intestinal microorganisms.
  • Demonstrated the involvement of Snhg9 in the progression of various human malignant tumors.
  • Highlighted the immune and metabolic influence of gut microbes on lncRNA expression and function.

Conclusions:

  • The interaction between lncRNA Snhg9 and gut microbiota is a critical factor in human cancer development.
  • Understanding these interactions provides a basis for developing novel cancer therapies.
  • Targeting the Snhg9-microbiota axis offers a promising avenue for future oncology research.
Keywords:
Gut microbiomeSnhg9biomolecular markercancerslong noncoding RNAsmicroRNAsregulation

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