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NIR-Responsive Carbon Dots Functionalized with AS1411 Aptamer: A Dual-Mode Approach to Enhanced Photothermal and
Kanchan Negi1, Sushmita Patra2, Ashok Kumar1
1Department of Chemistry and Chemical Biology, Indian Institute of Technology (Indian School of Mines), Dhanbad, Jharkhand 826004, India.
ACS Applied Bio Materials
|July 7, 2025
Summary
Researchers developed enhanced carbon dots (IRCDs@AS1411) from IR-820 dye for improved photodynamic and photothermal cancer therapy. These nanomaterials offer superior stability and efficiency for targeted tumor cell eradication.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Light-based therapies like photodynamic therapy (PDT) and photothermal therapy (PTT) are emerging cancer treatments.
- Combination therapy is crucial for enhancing efficacy and overcoming drug resistance in oncology.
Purpose of the Study:
- To synthesize and characterize novel carbon dots (IRCDs@AS1411) for improved PDT and PTT cancer treatment.
- To enhance the stability, photostability, and therapeutic efficiency of the near-infrared dye IR-820.
Main Methods:
- One-step hydrothermal synthesis of IR820-based carbon dots (IRCDs) from IR-820 and citric acid.
- Conjugation of AS1411 aptamers to IRCDs for targeted cancer cell delivery (IRCDs@AS1411) using EDC/NHS chemistry.
- Evaluation of photothermal conversion efficiency and in vitro bioimaging, PDT, and PTT efficacy.
Main Results:
- IRCDs@AS1411 exhibited enhanced chemical stability, photostability, and resistance to photobleaching compared to free IR-820.
- Photothermal conversion efficiency of IRCDs@AS1411 was approximately 35% higher than free IR-820.
- IRCDs@AS1411 demonstrated effective bioimaging, PDT, and PTT capabilities, leading to efficient tumor cell eradication under laser irradiation.
Conclusions:
- IRCDs@AS1411 represent a significant advancement over traditional organic dyes for cancer therapy.
- The developed nanomaterial platform shows great promise for targeted cancer treatment and the development of novel functional nanomaterials.
